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COLUMNISTS
TODAY'S STORIES
17.04.2008
Blinding Them With Science

David Baltimore is the president emeritus of the California Institute of Technology and the 1975 Nobel Laureate in Biology. Ahmed Zaweil was a colleague of his at C.I.T. and received the Nobel Prize in Chemistry in 1999. This morning, when from the shallow depths of pride the voices of the two remaining candidates for the Democratic presidential nomination were still piercing in my ears, these two master scientists and masters also of the ethics of science published a column in the Wall Street Journal. They began by reminding us that neither the Democratic aspirants nor John McCain had accepted the invitation of an eminent group, ScienceDebate2008, to address, preferably in a forum, the fact that a decline in science in the country actually threatens the country. I posted a spine about this failed forum a few days ago.

 

Baltimore and Zaweil write:

 

Protecting that future starts with understanding that much of the wealth in this country comes from scientific research and technological innovation. Translating science into commerce has opened up vast new fields of endeavor and has raised the standard of living in America. The country that is on the cutting edge of developing new technology is the country best positioned to benefit from that new technology.

 

A clear example is biotechnology. The U.S. is a leader here, and is able to capitalize on its pre-eminence with disease-resistant crops, anticancer drugs and much more. By developing a strong understanding of the basic science that underlies advances in biotechnology, we are also creating a good training ground for a future generation of scientists and innovators.

 

But America cannot simply assume its lead in science will continue. In recent years the science community has been starved of the resources it needs. Young, new, energetic scientists are the seed corn of nearly all new scientific development. However, our schools, laboratories and granting agencies all, in one way or another, discourage launching a career in the sciences. There are few grants to live on; and both schools and laboratories have long since lost the sense of joy we remember from our younger days. Science can be exciting and attractive. But convincing bright students to become scientists requires a lot more than we are now providing.

 

They also make the point that the average age of a National Institute of Health grantee with a PhD is 42, of a grantee with an MD is 44. This is an irrational outcome that shouldn't be simply manipulated down the age scale. There should be a tremendous increase in the allocations to the N.I.H. and the other research-supporting agencies.

 

In fact, without such a change, we are sabotaging the American future, just as we are with leaving the national infrastructure without the attention it needs. Sarah Goldhagen wrote about this challenge in TNR.

 

Alas, these two matters have received almost zilch attention. I don't think the question of patriotism can honestly be raised against any of the candidates, except in the fact that they brazenly ignore what should be on the top of their agendas.

 

Posted: Thursday, April 17, 2008 6:26 PM with 12 comment(s)

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maxzig1 said:

It is even worse than that - that actual quote is "At the National Institutes of Health, the average age of a FIRST grant is 42 for a Ph.D. and 44 for an M.D."  To be fair, that is the average age of receiving your first R01, which is the major large grant given to individual PIs (Principlal Investigators) - the kind of grant that lets you run a full lab.  There are a number of grants which scientists often pursue until (and after) that first R01 comes in but these grants are both smaller and shorter than the five-year R01.

This truly is keeping younger scientists from being able to pursue promising new ideas.  Increasingly, the way to get funding is to stick to small, safe projects which make incremental advances but have a greater chance of resulting in at least some sort of publication.  This funding situation is pushing science towards low risk, low reward research projects.

April 17, 2008 8:41 PM

jacksondyer said:

"This funding situation is pushing science towards low risk, low reward research projects."

Low risk, low reward projects, welcome to post modern times.

April 17, 2008 9:49 PM

teplukhin2you said:

Yet another example of the way Tweedledum and Tweedledee ignore the really major issues facing our fragile world leadership role. As with so many issues - Mexico policy, NATO's collapse, race-based affirmative action, schools policy - each party sees no political upside in telling the nation some hard truths when it comes to scientific excellence.

Tweedledum, besotted as always with identity politics and academic grievance-shopping, views excellence in any field dominated by elite males as suspect in and of itself, and would rather fund college women's field hockey programs, Queer Studies, anything but basic scientific research of the sort that validates Larry Summers' offhand remarks about distribution of talent by gender.

Tweedledee, besotted for its own part with the magic of the marketplace, aka faeries and unicorns, denies any role to federal funding in preserving our vanishing lead in scientific research. DARPA, the space program, land grant colleges, FLAS and other Cold War-era fellowships? Naah, leave it up to the private sector. We don't need to learn nothin' from those stinkin' Euros and Asians, anyway.

April 17, 2008 11:55 PM

ritebrother said:

I'm glad to see this issue wiggling its way into the mainstream.  I've been involved with the ScienceDebate2008 endeavor, and have been truly disappointed in the lack of response by the candidates.  The public is generally unaware of the vital role of Federal funding agencies (NIH and NSF) in driving biomedical research, which in my mind is heart of the problem; the candidates are unresponsive because the public is ignorant of the issue.  The public sees universities as simply a place where students get their ticket to play in the economy of the private sector.  There is very little understanding of the almost exclusive role of university research faculty in driving science research in the United States.  They don't understand that a biotech company is not going to invest in basic research without a specific marketable outcome on the very near horizon.  In reality, most breakthroughs in disease treatment result from findings in basic science labs at universities, whose publicly reported fiindings are adapted to therapy development.

As someone who is struggling to maintain a funding stream for my own lab, I can say that the situation has become dire, and the morale of biomedical research faculty is at the lowest point in my scientific career.  Paylines (the cutoff point for funding) at all NIH institutes has dropped to historically low levels, and is at less than 10% in some cases.  As maxzig1stated, it forces researchers to retreat to proposing safe projects that have pretty much already been mostly completed, or cynically framing their work as relevant to a disease that they really have no interest in, just to increase funding chances.  The heady days of discovery for its own sake is a fond memory of the past, something that today's junior faculty will sadly not likely experience.  The grant proposals that my preceptors routinely had funded would not even make it to a full review these days.

One very tangible outcome of this crisis will be that the entire model of the partnership between Federal agencies and academia will likely collaspe in the near future if these trends are not reversed.  Universities rely on research faculty to teach undergraduate and graduate courses, and train graduate students in thesis research, and to maintain a productive research program.  However, this is expected to be paid for by the faculty through Federal grant funding, the NIH R01 beiing the standard for the biomedical sciences.  Faculty are expected to pay part of their salaries, and to support their graduate students' tuition and stipend.  Indeed, extramural funding is a primary condition of tenure.  Soon, if not already, there will not be enough grants to fund the faculty base required to perform these functions, and universities will either have to pick up the tab (not going to happen), or revert to simple teaching institutions with no research or graduate school component.  This is not the fault of the faculty, or their science.  Unfortunately, solid science is no longer sufficient to garner funding.

April 18, 2008 9:47 AM

r-ennis said:

I am a believer in generously funding incubators for getting new technology, even if it a bit wacky, off the ground, but my experience with major federal funding grants to commercialize energy related technologies was very negative.

I had the opportunity to see T. Boone Pickens addressing a town hall meeting at Georgetown University Business School on C-Span last evening. His ideas on making the US energy independent trump anything I have heard elsewhere, and he has the wherewithal to make much of it happen with little or no government involvement.

Other areas of science, such as biotech may be very different, but my experience with government backed university research is also negative. The emphasis is on getting grant money. Commercialization is an afterthought.  

April 18, 2008 3:14 PM

blackton said:

come on now, we can just keep on importing all of our scientists from India and China. Let us not pretend we don't either. Good lord, Americans going back to science would put me out of business since I have been teaching English to a whole generation of people whose main goal is to make money in the states.

April 18, 2008 4:57 PM

lymon1 said:

Unqualified praise for Marty's post.

Blackton -- yet importing scientists from India and China (and during the 1990's we were brain-draining Canada!) is tied to our monetary policy (Iraq/tax cuts = weak dollar = less attraction) -- all these issues fall into a maddening stew!

There's a parallel discussion here for importing doctors and, especially, nurses.  

April 18, 2008 5:34 PM

JEFF FREY said:

The situation largely the same in other areas of science, if not worse. In fact, to those of us in Earth Scieces, the biomedical types have looked like they were on the gravy train, because the NIH budget was climbing much faster than other areas of science. But the NIH budget has now flatlined, and biomedical sciences are probably now facing the problem of what happens when you are accelerating and suddenly hit a wall.

Proposal success rates in my area of research, and related fields, have dropped by a factor of 2 in the last few years. They are now low enough that the problems ritebrother describes are all present in my field. On top of that, I am worried about whether peer review of research proposals is going to survive -- if you think that the best chance to get funded is by anonymously cutting the throats of your peers by subtly trashing their proposals, some people will do it because the penalties of not getting funded (not getting paid, not getting tenure = getting fired) are very high.

R-ennis, I think you are missing the point. You are talking about what is more at the Development end of Research and Development. Although that part is important, once new technologies or techniques reach the point where commercial applications become visible, there are a variety of ways to take it the rest of the way (and once something is clearly commercially viable, the private sector will absolutely take over). The problem is with the basic research end of things. Today's basic research is what leads to tomorrow's applied research, commercialization, new products, better weather forecasts, better natural hazard forecasting and warnings, etc.

In the 1960s there were a number of corporate labs that carried out a wide range of basic research, often on ideas and technologies that were years to decades away from commercial applications. Some of that included "blue sky" research that led to totally unexpected technologies down the road. Today, the only entity left that supports this kind of research across the board is the Federal government. If we want to see stagnation in applied research and development of new technologies in a decade or two, the surest way to achieve that is cut basic research today.

Importing scientists is not the answer -- that has been the answer for a generation. We attracted them because the US was the best place to do research, so we have been able to draw scientists not just from China and India and other places where coming here was a big economic step up, but also many scientists from developed countries. If we let our research base stagnate, they will not come. Instead, we will start to be on the losing end of the brain drain. Because you had better believe that Europe and the developed economies of Asia are not stopping their support for scientific research. Even China, which is a mix of developed and backward, is starting to develop significant research capabilities, and is producing an astonishing number of engineers.

But we can always support ourselves by selling flag lapel pins to Presidential candidates, I guess, even if we let our edge over the rest of the world disappear.

April 18, 2008 8:41 PM

maxzig1 said:

JEFF,

Ironically, those of us in the NIH funded medical sciences are now being advised to apply for DoD or NSF grants because the pay lines are higher than those of the NCI.  I feel your pain though, your Earth Sciences funding cycle was down for several years while the NIH's was still in "the doubling."

Survive the droughts, I wish you well.

Science is getting starved in this country because it can not be manipulated to political ends.  But it will come back in fashion, because everyone likes reality-based results.

April 19, 2008 3:03 AM

sleepyavl said:

Congratulations to Marty for this post!

The funding situation is really bad. In UK, Germany and Japan labs are much better funded.

US is losing. It's not a matter of importing people from China and India. It's that without funding, things are going down. Which is what has been happening in the past eight years here.

April 19, 2008 3:09 AM

JEFF FREY said:

Thanks for the kind thoughts, maxzig1. Good luck to you as well.

April 20, 2008 7:37 PM

The Plank said:

I know everyone's still preoccupied with Obama's "bitter" comments, but I'd argue

April 22, 2008 10:48 AM

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